Ischemic Stroke

Lampl Y, Zivin JA, Fisher M, Lew R, Welin L, Dahlof B, Borenstein P, Andersson B, Perez J, Caparo C, Ilic S, and Oron U.  Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1). Stroke. 2007;38:1843 -1849.

PhotoThera Preclinical Studies

Ischemic Stroke

Lapchak PA, Salgado KF, Chao CH, Zivin JA. Transcranial near-infrared light therapy improves motor function following embolic strokes in rabbits: an extended therapeutic window study using continuous and pulse frequency delivery modes. Neuroscience. 2007;148(4):907-14.

Oron A, Oron U, Chen J, Eilam A, Zhang C, Sadeh M, Lampl Y, Streeter J, DeTaboada L, and Chopp M. Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits. Stroke. 2006;37:2620-2624.

Ilic S, Leichliter S, Streeter J, Oron A, DeTaboada L, and Oron U. Effects of power densities, continuous and pulse frequencies, and number of sessions of low-level laser therapy on intact rat brain. Photomedicine and Laser Surgery. 2006;24(4):458-466.

DeTaboada L, Ilic S, Leichliter-Martha S, Oron U, Oron A, and Streeter J. Transcranial application of low-energy laser irradiation improves neurological deficits in rats following acute stroke.  Lasers in Surgery and Medicine. 2006;38:70-73.

Lapchak PA, Wei J, and Zivin JA.  Transcranial infrared laser therapy improves clinical rating scores after embolic strokes in rabbits. Stroke. 2004;35:1985-1988.

Traumatic Brain Injury

Oron A, Oron U, Streeter J, deTaboada L, Alexandrovich A, Trembovler V, Shohami E. Low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits. Journal of Neurotrauma. 2007;24(4):651-656.

General

Oron U, Ilic S, De Taboada L, Streeter J.  Ga-As (808 nm) laser irradiation enhances ATP production in human neuronal cells in culture.  Photomed Laser Surg. 2007;25(3):180-2.

Streeter J, De Taboada L, and Oron U. Mechanisms of Action of Light Therapy for Stroke and Acute Myocardial Infarction. Mitochondrion. 2004;4:569-576.

Lychagov VV, Tuchin VV, Vilensky MA, Reznik BN, Ichim T, and De Taboada L. Experimental Study of NIR Transmittance of the Human Skull. Complex Dynamics and Fluctuations in Biomedical Photonics III, Proc. of SPIE. 2006;6085 (60850T):1-5.

Selected Publications on Therapeutic Near-Infrared Light

Desmet KD, Paz DA, Corry JJ, Eells JT, Wong-Riley MTT, Henry MM, Buchmann EV, Connelly MP, Dovi JV, Liang HL, Henshel DS., Yeager RL, Millsap DS., Lim J, Gould LJ, Das R, Jett M, Hodgson BD, Margolis D, and Whelan HT. Clinical and experimental applications of NIR-LED photobiomodulation.  Photomedicine and Laser Surgery. 2006;24(2):121-128.

Eells JT, Henry MM, Summerfelt P, Wong-Riley MTT, Buchmann EV, Kane M, Whelan NT and Whelan HT. Therapeutic photobiomodulation for methanol-induced retinal toxicity. PNAS. 2003;100(6):3439-3444.

Eells JT, Wong-Riley MT, VerHoeve J, Henry M, Buchman EV, Kane MP, Gould LJ, Das R, Jett M, Hodgson BD, Margolis D, Whelan HT. Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy. Mitochondrion. 2004;4(5-6):559-67.

Karu T. Mechanisms of low-power laser light action on cellular level. Proc of SPIE. 2000;4159:1-17.

Lane N. Cell biology: power games. Nature. 2006;443(7114):901-3.

Oron U, Yaakobi T, Oron A, Mordechovitz D, Shofti R, Hayam G, Dror U, Gepstein L, Wolf T, Haudenschild C, Haim SB. Low-energy laser irradiation reduces formation of scar tissue after myocardial infarction in rats and dogs. Circulation. 2001;103(2):296-301.

Passarella S, Ostuni A, Atlante A, and Quagliariello E. Increase in the ADP/ATP exchange in rat liver mitochondria irradiated in vitro by helium-neon laser.  Biochem BioPhys Res Commun. 1988;156(2):978-986.

Wong-Riley MTT, Liang HL, Eells JT, Chance B, Henry MM, Buchmann E, Kane M, and Whelan HT.  Photobiomodulation directly benefits primary neurons functionally inactivated by toxins.  J. Biol. Chem. 2005;280(6): 4761-4771.

Wong-Riley MTT, Xuetao B, Buchmann E, Whelan HT.  Light-emitting diode treatment reverses the effect of TTX on cytochrome oxidase in neurons. Neuroreport. 2001;12(14):3033-3037.