PhotoThera Clinical Trials

Ischemic Stroke

Zivin JA, et al.  Effectiveness and Safety of Transcranial Laser Therapy for Acute Ischemic Stroke. Stroke. 2009;40:1359-1364.

PhotoThera Preclinical Studies

Ischemic Stroke

Andrew B. Stemer, Branko N. Huisa, Justin A. Zivin. The Evolution of Transcranial Laser Therapy for Acute Ischemic Stroke, Including a Pooled Analysis of NEST-1 and NEST-2. Curr Cardiol Rep. 2010 January;12(1):29–33.

Paul A. Lapchak, Luis De Taboada.  Transcranial near infrared laser treatment (NILT) increases cortical edenosine-5'-trphosphate (ATP) content following embolic strokes in rabbits.  Brain Research. 1306 (2010) 100-105.

Paul A. Lapchak, Moon-Ku Han, Karmen F. Salgado, Jackson Streeter and Justin A. Zivin. Safety Profile of Transcranial Near-Infrared Laser Therapy Administered in Combination With Thrombolytic Therapy to Embolized Rabbits. Stroke. 2008;39;3073-3078.

Lapchak PA, Salgado KF, Chao CH, Zivin JA. Transcranial near-infrared light therapy improves motor function following embolic strokes in rabbits: an extended therapeutic window study using continuous and pulse frequency delivery modes. Neuroscience. 2007;148(4):907-14.

Oron A, Oron U, Chen J, Eilam A, Zhang C, Sadeh M, Lampl Y, Streeter J, DeTaboada L, and Chopp M. Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits. Stroke. 2006;37:2620-2624.

Ilic S, Leichliter S, Streeter J, Oron A, DeTaboada L, and Oron U. Effects of power densities, continuous and pulse frequencies, and number of sessions of low-level laser therapy on intact rat brain. Photomedicine and Laser Surgery. 2006;24(4):458-466.

DeTaboada L, Ilic S, Leichliter-Martha S, Oron U, Oron A, and Streeter J. Transcranial application of low-energy laser irradiation improves neurological deficits in rats following acute stroke. Lasers in Surgery and Medicine. 2006;38:70-73.

Lapchak PA, Wei J, and Zivin JA. Transcranial infrared laser therapy improves clinical rating scores after embolic strokes in rabbits. Stroke. 2004;35:1985-1988.

Traumatic Brain Injury

Oron A, Oron U, Streeter J, De Taboada L, Alexandrovich A, Trembovler V, Shohami E. Low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits. Journal of Neurotrauma. 2007;24(4):651-656.

Neurodegenerative Diseases

Luis De Taboada, Jin Yu, Salim El-Amouri, Sebastiano Gattoni-Celli, Steve Richieri, Thomas McCarthy, Jackson Streeter, and Mark S. Kindy. Transcranial Laser Therapy Attenuates Amyloid-β Peptide Neuropathology in Amyloid-β Protein Precursor Transgenic Mice. Journal of Alzheimer's Disease. 23 (2011) 521-535.

Patricia A Trimmer, Kathleen M Schwartz, M Kathleen Borland, Luis De Taboada, Jackson Streeter, and Uri Oron. Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy. Molecular Neurodegeneration. 2009, 4:26.

General

Fulbha K. Sharma, PhD, Gitika B. Kharkwal, PhD, Mari Sajo, MS, Ying-Ying Huang, MD, Luis De Taboada, FSEE, Thomas McCarthy, DVM, and Michael R. Hamblin, PhD. Dose Response Effects of 810 nm Laser Light on Mouse Primary Cortical Neurons. Lasers in Surgery and Medicine. 43:851-859 (2011)

McCarthy T, D.V.M., DeTaboada, MSEE, Hildebrandt P, D.V.M., Ziemer E, D.V.M., Ph.D., Richieri S, B.S. Pharm., and Streeter J, M.D. Long-Term Safe of Single and Multiple Infrared Transcranial Laser Treatments in Sprague-Dawley Rats. Photomedicine and Laser Surgery. 2010;28:663-667.

Oron U, Ilic S, De Taboada L, Streeter J, Laser irradiation enhances ATP production in human neuronal cells in culture. Photomed Laser Surgery. 2007;25(3):180-2.

Lychagov VV, Tuchin VV, Vilensky MA, Reznik BN, Ichim T, and De Taboada L. Experimental Study of NIR"> Experimental Study of NIR Transmittance of the Human Skull. Complex Dynamics and Fluctuations in Biomedical Photonics III. Proc. of SPIE. 2006;6085 (60850T):1-5.

Streeter J, De Taboada L, and Oron U. Mechanisms of Action of Light Therapy for Stroke and Acute Myocardial Infarction. Mitochondrion. 2004;4:569-576.

Selected Publications on Therapeutic Near-Infrared Light

Lane N. Cell biology: power games. Nature. 2006;443(7114):901-3.

Desmet KD, Paz DA, Corry JJ, Eells JT, Wong-Riley MTT, Henry MM, Buchmann EV, Connelly MP, Dovi JV, Liang HL, Henshel DS., Yeager RL, Millsap DS., Lim J, Gould LJ, Das R, Jett M, Hodgson BD, Margolis D, and Whelan HT. Clinical and experimental applications of NIR-LED photobiomodulation. Photomedicine and Laser Surgery. 2006;24(2):121-128.

Wong-Riley MTT, Liang HL, Eells JT, Chance B, Henry MM, Buchmann E, Kane M, and Whelan HT. Photobiomodulation directly benefits primary neurons functionally inactivated by toxins. J. Biol. Chem. 2005;280(6):4761-4771.

Eells JT, Wong-Riley MT, VerHoeve J, Henry M, Buchman EV, Kane MP, Gould LJ, Das R, Jett M, Hodgson BD, Margolis D, Whelan HT. Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy. Mitochondrion. 2004;4(5-6):559-67.

Eells JT, Henry MM, Summerfelt P, Wong-Riley MTT, Buchmann EV, Kane M, Whelan NT, and Whelan HT. Therapeutic photobiomodulation for methanol-induced retinal toxicity. PNAS. 2003;100(6):3439*3444.

Wong-Riley MTT, Xuetao B, Buchmann E, Whelan HT. Light-emitting diode treatment reverses the effect of TTX on cytochrome oxidase in neurons. Neuroreport. 2001;12(14):3033-3037.

Oron U, Yaakobi T, Oron A, Mordechovitz D, Shofti R, Hayam G, Dror U, Gepstein L, Wolf T, Haudenschild C, Haim SB. Low-energy laser irradiation reduces formation of scar tissue after myocardial infarction in rats and dogs. Circulation. 2001;103(2):296-301.

Karu T. Mechanisms of low-power laser light action on cellular level. Proc of SPIE. 2000;4159:1-17.

Passarella S, Ostuni A, Atlante A, and Quagliariello E. Increase in the ADP/ATP exchange in rat liver mitochondria irradiated in vitro by helium-neon laser. Biochem BioPhys Res Commun. 1988;156(2):978-986.